α-2b干扰素对柯萨奇B组病毒抗原清除效应的研究

A Study of Interferon α-2b in Eliminating CVB Antigen

系统探讨α－２ｂ干扰素在呼吸道感染儿对阳性的柯萨奇Ｂ组病毒抗原（ＣＶＢ－Ａｇ）的消除效应。ＣＶＢ－Ａｇ阳性呼吸道感染病儿３８例，其中上呼吸道感染１６例，下呼吸道感染２２例，年龄２～１０岁，平均４．５５＋３．８１岁，男２１例，女１７例。分Ａ（１８例），Ｂ（２０例）２组。ＣＶＢ－Ａｇ和ＣＶＢ－ＩｇＭ测定采用ＥＬＩＳＡ法。α－２ｂ干扰素，皮下或肌肉注射５～７天，每天１００万Ｕ。连续３周观测２组ＣＶＢ－Ａｇ阳性率变化，并分析ＣＶＢ性心肌炎发生率。结果显示：（１）用α－２ｂ干扰素后１～２周抗原阳性率明显降低（Ｐ＜０．０５）。（２）用α－２ｂ干扰素后ＣＶＢ性心肌炎发病率明显降低（Ｐ＜０．０１）。（３）α－２ｂ干扰素不良反应轻。提示α－２ｂ干扰素有快速消除ＣＶＢ抗原的功效，并对降低ＣＶＢ性心肌炎的发病有益。

To study systemically the therapeutical efficacy of interferon α-2b in cosackievirus B(CVB) in children with respiratory infection, 38 with cosackievirus B antigen (CVB-Ag) positive respiratory tract infection cases were divided into two groups: Group A(18 cases), routine treatment and Group B(20 cases), routine treatment plus interferon α-2b. CVB-Ag and CVB-IgM were tested by ELISA method. Interferon α-2b was injected, subcutaneously or intramuscularly for 5～7 days, 1 million U a day. The results showed that (1) the CVB-Ag positive rate was significantly decreased one or two weeks after using interferon α-2b;(2) there was lower incidence of CVB myocarditis in interferon α-2b group; (3) the adverse reaction was mild. Conclusions: Interferon α-2b was demonstrated rapid eliminating effect of CVB-Ag and provided the benefit of lowering the incidence of CVB myocarditis.