七叶皂苷钠对脊髓型颈椎病术后疗效的前瞻性研究

Prospective Study the Curative Effects of Sodium Aescinat to Cervical Spondylotic Myelopathy

目的观察七叶皂苷钠对脊髓型颈椎病术后疗效的影响。方法将符合病例纳入标准的72例脊髓型颈椎病患者随机分成治疗A组、治疗B组和对照组。治疗A组手术前后均应用七叶皂苷钠治疗,治疗B组仅术后应用七叶皂苷钠治疗,对照组术后应用甘露醇治疗;通过JOA评分法观察三组患者第7d症状改善情况。结果治疗组疗效明显优于对照组,差异有统计学意义（P〈0.01）,治疗A组的疗效高于治疗B组,差异有统计学意义（P〈0.05）。结论七叶皂苷钠对脊髓型颈椎病术后神经功能恢复具有确切的辅助疗效,且手术前后联合应用比单独术后应用效果更好。

Objective TO observe the curative effects of Sodium aescinat to cervical spondylotic myelopathy. Methods The cases of standard correspond in 72 cases with cervical spondylotic myelopathy randomly divided into treatment group A, group B and control group. Cases in group A were injected Sodium aescinal injection preoperation and postoperation on cervical spoodylotic myelopathy; Cases in group B were injected Sodium aescinat injection only postoperation on cervical spondylotic myelopathy： Cases in group control were injected mannitol injection postoperation on cervical spondylotic myelopathy： At seven day, to observe Cases in group A, group B and control group through JOA grade.Result The curative effect of treatment group was better than control group, the difference was statistically significant （P^0.01）, the treatment effect of the treatment group A than B, the difference was statistically significant （P〈0.05）. Conclusion Sodium aescinat to cervical spondylotic myelopathy postoperative neurological recovery has assisted effect, and surgery combined application effect is better than single postoperative applications.