摘要
目的研究国产卡铂(CBP)的临床药代动力学与药效学。方法12例肿瘤病人静滴CBP400mg。用反相高效液相色谱法测定血清CBP浓度;按1978年常州会议制定的标准作疗效评定。结果静滴结束时的平均血药浓度(Co)为54.79±1181mg.ml-1,消除半衰期(T1/2β)为143.12±49.41min。有4例部分缓解(PR),8例稳定(NC)或进展(PD)。有效组(PR)和无效组(NC+PD)的Co分别为61.03±9.28和52.14±12.77mg.L-1,T1/2β分别为191.27±26.92和119.00±35.31min(P<0.01)。在2~10h内,有效组血清CBP浓度高于无效组(P<0.05)。结论肿瘤病人静滴CBP的血药浓度存在明显个体差异。
Objective:To study the clinical pharmacokinetics and pharmacodynamics of carboplatin.Methods:Serum carboplatin levels in 12 patients with cancer and being treated by intravenous drip of carboplatin were determined by reversed-phase HPLC.And responses to treatment were evaluated according to the criteria made at Changzhou Meeting in 1978.Results:The average serum carboplatin level(Co) was 54.79±11.81 mg.L -1 at the end of intravenous drip.The half-life(T 1/2β ) of carboplatin was 143.12±49.41 minutes.The outcome of carboplatin treatment was as follows:partial remission (PR) in 4 cases(33.3%),no change (NC) or progress of disease (PD) in 8 cases(66.7%).The average levels of Co were 61.03±9.28 and 52.14±12.77mg.L -1 ,and T 1/2β 191.27±26.92 and 119.00±35.31 minutes( P <0.01)in effective and ineffective groups,respectively.After intravenous drip,the serum carboplatin levels in effective group were higher than those in ineffective one from 2 to 10 hours ( P <0.05).Conclusion:The individual serum carboplatin levels vary significantly in patients with cancer after intravenous drip.The therapeutic effects of carboplatin is related to its serum levels and parameters of elimination.
出处
《泰山医学院学报》
CAS
1999年第1期6-9,共4页
Journal of Taishan Medical College