糖原合成酶激酶3在阿尔茨海默病中的作用

Role of glycogen synthase kinase 3 in Alzheimer's disease

糖原合成酶激酶-3(glycogen synthase kinase-3,GSK-3)作为体内主要的蛋白激酶之一,广泛地参与了生长发育、凋亡衰老和肿瘤形成等重大生命过程。GSK-3β-Ser9和GSK-3α-Ser21位点的磷酸化修饰是机体对GSK-3活性调控的关键过程,GSK-3参与了tau蛋白过度磷酸化修饰、β淀粉样蛋白异常聚集和神经元凋亡等过程,因此对GSK-3活性调控的研究是阿尔茨海默病等神经退行性疾病的发病机制和相关治疗研究中的焦点问题之一。

As a key protein kinase in cell,glycogen synthase kinase-3（GSK-3） is widely involved in the life processes such as development,aging,tumor formation,apoptosis and so on.Phosphory-lation of the sites in GSK-3β-Ser9 and GSK-3α-Ser21 is the major mechanism to regulate the GSK-3 activity.It has been shown that GSK-3 participates in the over phosphorylation of tau,abnormal aggregation of Aβ and the apoptosis of neuron,which is closely related to the pathogenesis of Alzheimermer＇s disease.Therefore,the research on the regulation of GSK-3 activity attracts great attention due to its key role in the pathogenesis of Alzheimer＇s disease and other neurodegenerative diseases.