氧化代谢酶对化学致癌物的活化与致癌作用

Oxidative metabolism enzymes on the activation of chemical carcinogens and carcinogenic effects

许多化学致癌物需要经代谢活化形成能与DNA等生物大分子作用的终致癌物,才能发挥致癌效应。癌症的发生是多基因参与多阶段发展的复杂过程。终致癌物可在癌症形成的各个阶段引起DNA损伤并启动基因突变。除细胞色素P450和前列腺素合成酶是参与致癌物活化最常见的途径外,脂氧合酶也与这些化学物的致癌作用有关。

Many chemical carcinogens require metabolic activation to form ultimate carcinogens,which can bind with DNA and other biological macromolecules and then exert a carcinogenic effect.The development of cancer is a complicate process that multiple genes and multiple stages are involved.Ultimate carcinogens can cause DNA damage and initiate gene mutation at all stages of the formation of can-cer.In addition to cytochrome P450 and prostaglandin synthase,the most common metabolic pathways,lipoxygenase also involves in activation of carcinogen.