MTDH在肿瘤发生、发展中的作用

Role of metadherin in the progress of tumors

异黏蛋白(metadherin,MTDH)是近来发现的一个新的癌基因,在多种肿瘤中过表达,包括乳腺癌、前列腺癌、食管癌、肝癌、神经母细胞瘤和恶性黑色素瘤,对乳腺癌细胞在肺中的定植有增强作用。MTDH增强肿瘤细胞的侵袭性,通过NF-κB途径增加黏附分子的表达。MTDH是Ha-ras下游基因,Ha-ras通过PI3K/AKT/GSK3β/c-Myc途径诱导MTDH大量表达。MTDH对多种肿瘤的发生和发展起着重要的作用,有望成为肿瘤靶向治疗的靶点。

Metadherin（MTDH） was reported as a novel oncogene in recent years.Overexpression of MTDH is frequently observed in a variety of tumors（such as breast,prostate,esophageal and liver cancer neuroblastoma and malignant melanoma） and can enhance the effects of colonization of breast cancer cells in the lungs.MTDH is able to enhance invasiveness of tumor cells and increase the expression of adhesion molecules via NF-κB pathway.MTDH is a downstream target gene of the oncogene Ha-ras,which induces the expression of MTDH through the PI3K/AKT/GSK3β/c-Myc signaling pathway.MTDH plays an important role in the occurrence and development of tumors,and is expected to become the site of tumor target for therapy.