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DLK1与肿瘤的关系 被引量：1

DLK1 and neoplasms
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摘要 DLK1(delta drosophila homolog-like 1或delta-like 1 homologue)是表皮生长因子(EGF)家族成员之一,作为细胞分化调节的重要因子,DLK1具有广泛的生物学功能。近年来研究证实DLK1在许多肿瘤组织中高表达,通过多种机制参与肿瘤的发生、发展。 Delta drosophila homolog-like 1（DLK1） is a member of the epidermal growth factor family.As an important factor in regulation of cell differentiation,DLK1 has a wide rang of biological functions.Recently,many studies have shown that the expression of DLK1 is up-regulated in many tumor tissues,which may be involved in the occurrence and development of neoplasms through a variety of mechanisms.
作者 张艳丽 康凯夫
机构地区 广东医学院病理学系 南方医科大学附属顺德第一人民医院病理科
出处 《国际病理科学与临床杂志》 CAS 2010年第3期251-254,共4页 Journal of International Pathology and Clinical Medicine
关键词 DELTA DROSOPHILA homolog-like1 肿瘤 基因 delta drosophila homolog-like 1 neoplasms genes
分类号 R730.2 [医药卫生—肿瘤]
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参考文献27

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二级参考文献22

  • 1Altenberger T, Bilban M, Auer M, et al. Identification of DLK1 variants in pituitary- and neuroendocrine tumors [ J ]. Biochem Biophys Res Commun, 2006, 340 (3) : 995-1005.
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  • 3Kawakami T, Chano T, Minami K. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma [J]. Hum Mol Genet,2006,15 (3) : 821-830.
  • 4Ditte C A, Stine J P, Louise H J, et al. Characterization of dlk 1^+ cells emerging during skeletal muscle remodeling in response to myositis, myopathies and acute injury [ J ]. Stem Cells Express, 2009, 8(1) : 1-19.
  • 5Moon Y S, Smas C M, Lee K. Mice Lacking patemally expressed pref-1/DLK1 display growth retardation and accelerated adiposity [ J ]. Mol Cell Biol, 2002, 22 (12) : 5585- 5592.
  • 6Liang Li, Stephen J F, Ravi B. Expression of DLK 1 in hemato -poietic ceils results in inhibition of differentiation and proliferation[J]. Oneogene, 2005,24(10) :4472-4476.
  • 7Qi X F, Chen Z X, Liu D D,et al. Expression of DLK1 gene in myelodysplastic syndrome determined by microarray, and its effects on leukemia cells [ J ]. Int J Mol Med, 2008, 22(1) :61-68.
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国际病理科学与临床杂志
2010年 第3期

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