摘要
目的探讨妊娠高血压综合征(PIH)患者血管内皮生长因子(VEGF)、血清妊娠相关血浆蛋白-A(PAPP-A)、D-二聚体(D-D)和N-乙酰-β-D-氨基葡萄糖甙酶/肌酐(NAG/Cr)比值的变化及意义。方法通过检测92例PIH患者和35例健康妊娠孕妇PAPP-A、VEGF、D-D和NAG/Cr的水平,分析其与PIH的关系。结果妊娠高血压综合征患者VEGF水平显著低于健康对照组,差异有统计学意义(P<0.01),且随着病情的加重而显著降低,而PAPP-A、D-D、NAG/Cr水平显著高于健康对照组,差异有统计学意义(P<0.01);且随着病情加重PAPP-A、D-D、NAG/Cr水平显著增高。结论 VEGF、PAPP-A、D-D、NAG/Cr与PIH的发生、发展密切相关,动态监测其水平变化对于PIH患者的病情判断、临床治疗均有重要意义。
Objective To study the clinical significance of changes of blood contents of vascular endothelial growth factors （VEGF）.Pregnancy-associated plasma protein-A（PAPP-A）,D-dimers（D-D）and Urinary N-acetyl-β-D-glucosaminidase/Creatinine （NAG/Cr）Ratio in patients with Pregnancy Induced Hypertension syndrome（PIH）.Methods Serum VEGF and PAPP-A（with ELISA）,plasma D-dimers（with biochemistry）and NAG/Cr（with velocity）contents were measured in 92 pregnant women with PIH and 35 controls.Results The serum VEGF contents in patients with PIH were significantly lower than those in controls（P〈0.01）while PAPP-A,D-dimers and NAG/Cr contents were significantly higher（P〈0.01）.Those changes were especially marked in patients with advanced diseases.Conclusion Changes of blood contents of VEGF,PAPP-A D-dimers and Urinary NAG/Cr Ratio were closely related with the disease process of PIH.Determination of these changes was of clinical diagnostic as well as prognostic value.
出处
《国际检验医学杂志》
CAS
2010年第6期561-562,564,共3页
International Journal of Laboratory Medicine
关键词
妊娠并发症
高血压
内皮生长因子
妊娠相关α血浆蛋白质
实验室技术和方法
pregnancy complications
hypertension
endothelial growth factors
pregnancy associated alpha plasma protein
Laboratory Techniques and Procedurespregnant induced hypertension syndrome（PIH）
VEGF
PAPP-A
D-dimers
