代谢综合征患者血清淀粉样蛋白A水平与胰岛素抵抗的关系

Relationship between serum amyloid A and Insulin resistance in patients with metabolic syndrome

目的探讨代谢综合征患者血清淀粉样蛋白A水平与胰岛素抵抗的关系。方法对40例代谢综合征患者身高、体重、腰围、SBP及DBP进行测量,同时测定血清甘油三酯(TG)、胆固醇(TC)、空腹血糖(FPG)、高密度脂蛋白胆固醇(HDL)等生化指标,并与30例健康体检者进行对比分析。结果代谢综合征组血清SAA、HOMA-IR水平明显高于健康对照组(P<0.01),除年龄、身高、TC、LDL-C外,其余各指标两组比较差异均有统计学意义(P<0.01或P<0.05)。血清SAA与体重、BMI、腰围、收缩压、LDL-C、FINS、HOMA-IR呈正相关,与HDL-C呈负相关。结论 SAA水平的检测可能是早期发现代谢综合征高危人群的手段之一。

Objective To probe the relationship between serum amyloid A and insulin resistance in patient with metabolic syndrome.Methods Parameters of body height,body weight,waistline,SBP,DBP,TG,TC,FPG,and HDL were measured in the group of 40 patients with metabolic syndrome while 30 healthy people were referred as control group.Results The level of serum SAA,HOMA,and IR were significantly higher than those of the control group（P〈0.01）,and the other parameters were also indicated significantly difference（except the parameters of age,height,TC,and LDL-C）.In patients of metabolic syndrome,the SSA had a positive correlation with body weight,waistline systolic pressure LDL-C,FINS,HOMA and IR,while the SSA had a negative correlation with HDL-C.Conclusion SAA is closely associated with insulin resistance,and it may serve as a marker in patients with metabolic syndrome