2种药物在抢救急性苯二氮卓类药物中毒患者中的应用

The Application of Two Drugs in Rescuing Patients Poisoned by Benzyldiazepoxides

目的比较氟马西尼与纳洛酮在急性苯二氮卓类药物（BZDs）中毒患者中的应用效果。方法选择90例急性BZDs中毒患者，随机将其分为氟马西尼组、纳洛酮组，各45例。氟马西尼组在常规治疗的基础上用氟马西尼0．25～0．5mg静脉注射，纳洛酮组则在常规治疗的基础上用纳洛酮0．8mg音争脉注射。比较2组患者的昏迷程度、平均意识恢复时间、所用剂量、费用和住院时间。结果治疗后30min、1h和4h，氟马西尼组患者的昏迷程度评分高于纳洛酮组（p均〈0．05），氟马西尼组患者的平均意识恢复时间、住院时间短于纳洛酮组（p均〈0．05），氟马西尼组患者所用剂量少于纳洛酮组（p〈0．05），费用低于纳络酮组（p〈0．05）。结论氟马西尼在快速催醒方面的效果优于纳洛酮，且缩短了平均住院时间及住院费用。

Objective：To compare the effect of using Flumazenil and Naloxone in patients poisoned by Benzyldiazepoxides（BZDs）.Methotis：90 patients poisoned by BZDs were randomly divided into Flumazenil group and Naloxone group,each group had 45 patients.The Flumazenil group was treated by Flumazenil with 0.25-0.5 mg intravenous injection based on the regular treatment,while the Naloxone group was treated by Naloxone with 0.8 mg intravenous injection based on the regular treatment.The degree of coma, consciousness recovering time, dosage,hospital expense, and hospital stays were compared with the two groups.Results：The score of coma degree of the patients in Flumazenil group was higher than that of the Naloxone group in 30 minutes,1 hour,and 4 hours （all ps〈0.05）. The consciousness recovering time and hospital stays were shorter in Flumazenil group than that of the Naloxone group （both ps〈0.05）.The dosage of drugs in Flumazenil group was less than that of the Naloxone group and the hospital expense was less as well （both ps〈 0.05）. Conclusion： Flumazenil works better in rescuing patients poisoned by BZDs,especially in shortening consciousness recovering time, hospital stays,and hospital expense.