福辛普利的降压疗效及对尿微量蛋白的影响

THE EFFECTS OF FOSINOPRIL ON BLOOD PRESSURE AND MICROALBUMINURIA IN ESSENTIAL HYPERTENSION

目的：观察双通道转换酶抑制剂福辛普利（ｆｏｓｉｎｏｐｒｉｌ）治疗原发性高血压的降压疗效及其对尿微量蛋白排泄的影响。方法：比较２４例高血压病Ⅱ期患者口服福辛普利（１０～２０ｍｇ／ｄ）４周前后血压、心率及２４ｈ尿微量蛋白的排泄，并比较了它们之间的相关关系。结果：服药后血压明显下降（Ｐ＜０．０５，Ｐ＜０．００１），尿微量蛋白排泄明显降低（Ｐ＜０．０５），两者无相关关系，降压总有效率为６３％，心率及内生肌酐清除率无明显变化。结论：福辛普利在对原发性高血压有明显的降压作用同时减少尿白蛋白排泄。

OBJECTIVE:To study the effects of fosinopril on blood pressure (BP)and micro albuminuria in essential hypertension patients.METHODS:The BP,heart rate and 24 hour urine microalbumine content before and after treatment with oral fosinopril(10～20 mg/d)for 4 weeks were measured in 24 patients with essential hypertension(Ⅱ stage).RESULTS:The BP was significantly decreased with a total effective rate of 63%( P <0.05, P <0.001)and urine microalbumine were also markedly reduced ( P <0.05)but no correlation between the two while with no change in heart rate and creatinine clearance were observed.CONCLUSION:Fosinopril is a drug with significant antihypertension activity and with an ability to decrease urine microalbumine, therefore,it may be benefit in renal protection for patients with essential hypertension.