]注射满口林格组行机械把氯化钠籍，观察jg组尿量组给药低于给l目显，未

To Study the Effects and Safety of Hyperonic Sodium Chloride Hydroxyethyl Starch 40 Injection in Traumatic Patients

目的研究高渗氯化钠羟乙基淀粉40注射液用于创伤病人手术的有效性和安全性。方法创伤评分（ISS）13～15分病人50例,随机分为高渗氯化钠羟乙基淀粉40组（H组）和林格组（R组）,每组25例。两组病人均采用静吸复合麻醉,诱导时依次静注芬太尼2ug/kg、阿曲库铵0.5mg/kg、丙泊酚2mg/kg、气管插管后行机械控制呼吸,麻醉维持吸入1～2%异氟醚,微量泵持续灌注阿曲库铵0.25～0.5mg？kg-1？h-1、丙泊酚2.5～5 mg？kg-1？h-1.H组：术前输入高渗氯化钠羟已基淀粉40注射液250ml,输注速度10ml/h。R组：仅常规输入林格氏液。于给药前和停药后30min检测血气,观察并记录Na＋Hct,观察并记录给药前、给药后5、10、15、20、25min和停药后30min的SBP、DBP、MAP、HR。术前放空尿袋,观察并记录停药后30min两组尿量。结果给药后5、10、15、20、25min和停药后30min,H组SBP、DBP、MAP均明显高于给药前（P〈0.05）,HR均低于给药前。H组给药后5、10、15、20、25min和停药后30min,SBP、DBP、MAP均高于R组（P〈0.05）,HR明显低于R组。停药后30min,H组Hct明显低于给药前（P〈0.05）。H组Hct明显低于R组（P〈0.05）,H组尿量明显高于R组（P〈0.05）。使用高渗氯化钠羟已基淀粉40注射液血压升高明显,未发现恶心、呕吐、皮肤潮红等不良反应。结论高渗氯化钠羟已基淀粉40注射液可以有效安全地用于创伤病人。

objective To study the effects and safety of hypertonic sodium chloride hydroxyethyl starch 40 injection in traumatic patients . Methods Fifty traumatic patients were randomly divided into two groups, hypertonic sodium chloride hydroxyethyl starch 40 injection group （H）, Ringre, s solution group （ R ）. Anesthesia was induced with intravenous injection of fantanyl （ 2pg/kg ）, atracurium （ 0.5mg/kg ）, propfol （ 2mg/kg ）. In H group, hypertonic sodium chloride hydroxyethyl starch 40 injection 250ml was injection, The rats was occluded for 10ml/b . In R group, Ringer, s solution was injection. Arterial blood samples were taken before injection and at 30 rain after injection, Hct and urine output were recorded. SBP, DBP, MDP, HR were recorded befor injection and at 5, 10, 15, 20, 25min and at 30rain after injection. Result In H group, SBP, DBP, MAP was drarnaticauy increased than that before injection at 5, 10, 15, 20, 25min （P〈0.05）, HR was decreased than that before injection. SBP, DBP, MAP in H group was dramalically increased than that in R group （P〈0.05）. Hct in H group was dramatically decreased than that in R group （P〈0.05）. Urine output in H group was dramatically increased than that in R group （P〈0.05）. Conclusion Hypertonic sodium chloride hydroxyethyl starch 40 injection can be used effectively and safely in traunatic patients.