抗心磷脂抗体、C-反应蛋白、平均动脉压联合预测孕早期妊娠高血压综合征的意义

Anticardiolipin antibodies,C-reactive protein,mean arterial blood pressure in early pregnancy in prediction of the significance of pregnancy-induced hypertension

目的测定孕早中期血抗心磷脂抗体(ACA)、C-反应蛋白(CRP)、平均动脉压联合预测妊娠高血压综合征的发生,寻求一种简便、易行并具有临床价值的预测方法。方法采用酶联免疫吸附法测定血ACA,乳胶免疫比浊法测定血CRP,同时测量平均动脉压进行研究。结果妊高征孕妇在孕10～16周CRP值、CAC阳性率及mABP≥85mmHg的发生率均较正常妊娠组明显升高,差异有统计学意义(P<0.01)。三者联合预测指标,阳性预测值为81.81%,阴性预测值98.64%,敏感度91.66%,特异度97.32%。结论孕早中期联合检测血ACA、CRP、平均动脉压有较高的敏感性和特异性。

Objective To determine the early and middle pregnancy blood anticardiolipin antibodies（ACA） ,C-reactive protein（CRP） ,mean arterial pressure in prediction of the occurrence of pregnancy induced hypertension,to find a simple,easy and have clinical value of forecasting methods. Methods By enzyme-linked immunosorbent assay of ACA,latex immunoassay for the measurement of blood CRP,simultaneous measurement of mean arterial blood pressure were studied. Results Of pregnant women with hypertension in pregnancy CRP value of 10 to 16 weeks,CAC-positive rate and the occurrence of mABP ≥ 85 mm Hg pregnancy rates were significantly higher than normal,the difference was statistically significant（P〈0. 01） . Predictor of the three combined,the positive predictive value of 81. 81%,negative predictive value of 98. 64%,sensitivity of 91. 66% and specificity of 97. 32% . Conclusion The combined detection of early and mid-pregnancy blood ACA,CRP,mean arterial blood pressure have higher sensitivity and specificity.