慢肾衰中高血压与内皮素-1关系的研究

目的通过测定慢肾衰患者的血压与血浆ET-1水平来评价两者之间的关系,推断ET对慢肾衰合并高血压患者肾损害的影响。方法取78例慢肾衰合并高血压患者(1级高血压24例,2级高血压28例,3级高血压26例)与36例慢肾衰不合并高血压的患者作为对照组。放射免疫法检测血浆ET水平。结果与对照组比较,慢肾衰合并高血压组的血浆ET升高,以2、3级患者明显。血压与血浆ET水平呈正相关(r=0.01,P<0.01)。结论 ET与高血压可能共同参与慢肾衰的肾损害的发生,发展过程。

Objective To research the correlation between hypertension and endothelin in chronic kidney failure patients.Methods The tension were measured by the mercuric tonometer in 78 patients with veritable hypertension and 36 normotensive constrasted.The plasma endothelin were measured by radioimmunoassay.Hypertensive patients,there were 24 casea in grade 1,28 cases in grade 2,26 cases in grade 3.Results The plasma endothelin increased in the patients,which was chronic kidney failure with hypertension,compared to the normoten-sive subjects.there was the positive relation between hypertension and endothelin（r=0.01,P〈0. 01） .Conclusion Plasma endothelin increased in the chronic kidney failure and hypertensive patients maybe involve.