联用卡马西平、多虑平治疗三叉神经痛的临床观察

Carbamazepine combined Doxepin treatment of idiopathic trigeminal neuralgia observation

目的观察卡马西平联合多虑平在特发性三叉神经痛治疗中的疗效和不良反应。方法卡马西平联合多虑平（治疗）组60例，卡马西乎（对照）组60例，均诊断为特发性三叉神经痛，用视觉模拟评分法给疼痛评分，通过治疗后1周、2周、1月、3月视觉模拟评分判断疗效。结果治疗组疗效明显高于对照组，治疗组患者疼痛积分（分别为5．3±1．82，1．8±1．79，1．6±0．96，0．62±0．94）显著低于对照组（6．1±1．74，4．5±1．27，3．36±1．22，2．7±1．14）（P〈0．05），卡马西平用量、不良反应发生率和程度均较对照组低。结论两种方法对特发性三叉神经痛均有效，但治疗组疗效更好，且不良反应发生率低，更安全。

Objective To observe the combined carbamazepine doxepin in the treatment of idiopathic trigeminal neuralgia the efficacy and adverse reactions. Methods Carbamazepine combined doxepin （treat- ment） group 60 eases, carbamazepine （control）group of 60 patients were diagnosed as idiopathic trigeminal neuralgia, using visual analogue scales for pain score, by 1 week after treatment,2 weeks, 1 month and 3 months visual analogue scale to determine efficacy. Results The efficacy of the treatment group were significantly higher than the treatment group the pain score （ respectively, 5.3 ± 1.82,1.8 ± 1.79,1.6 ±0. 96,0. 62 ± 0. 94） was significantly lower than the control group （ 6. 1 ± 1.74,4. 5 ±1.27,3.36 ±1.22,2.7 ± 1.14 ） （ P 〈 0. 05 ）, carbamazepine dosage, adverse reaction rates and extent of lower than those in the control group. Conclusion Both methods are valid for idiopathic trigeminal neuralgia, but the efficacy of the treatment group improved, and the incidence of adverse reactions is low, more secure.