乙型肝炎病毒感染与肝细胞性肝癌相关性的研究

The studying of hepatitis B virus and hepatocellular carcinoma

目的探讨乌鲁木齐地区维族汉族乙型肝炎病毒感染与肝癌关系。方法322例肝细胞性肝癌患者（其中维族150例，汉族172例）进行乙型肝炎病毒感染及ALT、AST、CA125、CA199、AFP的检测，并进行比较。结果HBsAg（＋）254例，其中维族阳性率77．3％（116例）与汉族阳性率80．2％（138例），差异无统计学意义。维族汉族肝癌患者ALT和AST的值分别为（845．57±54．25），（1382．36±125．34）和（798．85±69．17），（1405．82±151．2），差异均有统计学意义（P〈0．05）。维族汉族肝癌患者血清CA125、CA199、AFP差异均无统计学意义。结论乌鲁木齐地区肝癌患者血清乙型肝炎病毒感染率较高，可能是维族汉族肝癌的主要病原学因素。

Objective To explore the association of hepatitis B virus（HBV） with Hepatocellular carcinogenesis for Uygur and Han people in Urumqi region in Xin Jiang. Methods HBV,ALT,AST,CA125, CA199, and AFP were detected in 322 patients with Hepatocellular carcinogenesis（ 150cases were Uygur people and 172 cases were Han people）, and the compared results were analysed. Results There were 254 positive cases of HBsAg, and the positive rate for Uygur and Hart people was 77.3% （ 116 cases） and 80. 2% （ 138 cases） , respectively,and it was not statistically significant. The vale of ALT and AST for Uygur and Han people was （ 845.57± 54. 25 ）, （ 1382.36 ± 125.34 ） and （ 798.85± 69. 17 ）, （ 1405.82 ± 151.2 ）, respectively, and they were both statistically significant（ P 〈 0. 05 ）. The results of CA125, CA199, and AFP for Uygur and Han people were not statistically significant, either. Conclusion The detection rate of HBV is fairly high in patients with Hepatoce/lular carcinogenesis in Urumqi region in Xin Jiang, HBV may play an important role for etiology in hepatocellular carcinogenesis.