国产低分子肝素钙用于血液透析的抗凝作用

LOW MOLECULAR WEIGHT HEPARIN HOME MADE FOR ANTICOAGULATION DURING HEMODIALYSIS(HD)

目的：验证国产低分子肝素钙（立迈青）用于血液透析（血透）抗凝的疗效和安全性。方法：１５例患者作自身前后交叉对照观察，每例患者各使用立迈青或法安明（低分子肝素钠）进行血透５次，于血透开始时静脉推注立迈青或法安明５０００抗ＦＸａＩＵ，不用维持量。结果：２组患者顺利完成血透各７５例次；透析器容量（ＢＣＶ）减少率、透析１ｈ尿素即刻清除率、白陶土部分凝血活酶时间、血小板及抗ＦＸａ活性等２组间均无显著性差异（Ｐ＞００５）。结论：立迈青作为血透抗凝剂的疗效和安全性与法安明一致。

Objective:To compare the efficacy and safety of home made low molecular weight heparin(Livaracine) with that of Fragmin.Methods:Fifteen hemodialysis patients were studied in a radomized crossover fashion.All patients were randomized into Livaracine and Fragmin in five times HD.Livaracine or Fragmin was given at the initiation of hemodialysis in a single bolus dose of 5 000 anti FXa IU without maintanent dose.Results:Seventy five dialysis procedures with either Livaracine or Fragmin were performed successfully;blood compartment volume of dialyzers,1 hour clearance of urea,activated partial thromboplastin time,blood platelets count,anti FXa levels were comparable between these two groups( P >0 05).Conclusion:Livaracine was effective and safe like as Fragmin.