氟康唑治疗小儿鹅口疮197例疗效观察

目的探讨氟康唑治疗小儿鹅口疮的临床效果。方法 197例鹅口疮患儿被随机分为实验组(n=100)和对照组(n=97),两组均给予局部用药,实验组给予氟康唑治疗,对照组给予制霉菌素治疗。结果两组患儿均痊愈,痊愈率达到100%。但两组痊愈时间有显著性差异,实验组痊愈时间显著优于对照组(P<0.05)。结论制霉菌素较好的抗菌效果,但吸收较差,氟康唑也具有较好的临床疗效,而且吸收较好。因此我们认为,氟康唑用于鹅口疮患儿的治疗,能显著提高临床效果,缩短治疗时间,减少患儿痛苦,值得在临床上应用和推广。

Objective To explore the clinical effect of fluconazole used in treatment of children patients with thrush. Methods 197 cases of children patients with thrush were randomly divided into experimental group （n=100） and control group （n=97）.Both groups were given local medication, experimental group were given therapy of fluconazole, and control group was given therapy of nystatin. Results Both groups were cured, and the rate of cure reached up to 100%. There was significant difference between two groups about cure time, experimental group were significantly better than that control group （P〈0.05）.Conclusion Nystatin has good antibacterial effect, but absorbed not well; fluconazole has good clinical effect and absorbed efficiency. So we think, fluconazole used in treatment of children patients with thrush. can significantly enhance clinical effect, reduce treatment time and pain of patients, so it deserved application and promotion in clinical work.