新生儿脐血与足跟血TSH分析比较

目的通过本研究求证用脐血代替足跟血进行筛查的可行性,减少婴儿不必要的痛苦和污染,使家长能接受无创伤性筛查,提高筛查率,减少取血工作强度。方法只需在断脐时将脐静脉血装进试管即可送检(如为运输亦可制作成纸片)。检测脐血TSH含量,通过实验方法的灵敏度、重复性、特异性,与足跟血新生儿筛查进行平行追踪对比,求出新生儿脐带血的筛查切值。结果脐血与足跟血TSH95%位数分别为5～20IU/L、2～10IU/L,足跟血明显低于脐带血,需有各自的筛查切值。结论两种方法均可用于先天性甲低筛查。有各自的筛查切值。但新生儿脐带血血清只要严格掌握好采血时间,其优点多过足血。

Objective To improve the methods of getting blood sample in neonate screen. prove the feasibility of replacing the heel blood by umbilical blood in screen and decrease unnecessary pain and contamination, thus make the non-invasive screen adopted by parents, increase screen rate and facilitate the work of getting blood. Methods put umbilical blood into tube and send for test when breaking umbilical cord（and also can be made into paper for transportation）.The TSH content in umbilical blood is examined to determine the mean value of umbilical blood in neonate. in turn make it possible to screen out susceptible hypothyroidism neonate accurately and timely.Susceptiveness, repeatability and particularity are demanded in the test.TSH content examinations are performed in 5763 cases of heel blood and umbilical blood matched pair. Results umbilical blood and heel blood TSH 95% digit difference act 5～20IU/L, 2～10IU/L. heel blood low umbilical blood.Conclusion TSH in umbilical blood ranges from 5 to 20 and serum of umbilical blood in neonate can be used for screen of congenital hypothyroidism.