Ⅱ型糖尿病并消化性溃疡的临床研究

目的探讨Ⅱ型糖尿病(T2DM)并消化性溃疡(PU)的临床特点、根除幽门螺杆菌(HP)感染率及根除HP治疗效果。方法 T2DM并PU56例为观察组,对照组为随机选择与观察组同期内非糖尿病经胃镜检出的PU患者62例,2组均按常规进行胃镜检查和HP感染检测,分析2组的临床特点、溃疡部位、HP阳性率,HP阳性者采用奥美拉唑20mgbid,阿莫西林1000mgbid,甲硝唑400mgbid一周疗法,停用抗菌素后4周复查14C-尿素呼气试验,计算其根除率,比较2组差异。结果 2组在节律性疼痛症状,胃溃疡的检出有显著差异性(P<0.05),2组HP感染率无显著差异性(P>0.05),T2DM并PU的HP根除率为61.5%(24/39),显著低于对照组根除率88.0%(44/50)(P<0.05)。结论 2组临床症状、溃疡发生部位有所不同,而HP感染率却无差异;T2DM组的PU患者三联根除HP治疗的根除率低于非糖尿病组。

Objective To investigate the clinical characteristics of type-2 diabetes mellitus and peptic ulcer,and the eradication rate of Helicobacter pylori（HP）treatment.Methods T2DM and PU 56 cases for the observation group,the control group 62 patients was randomly selected with the same period in the observation group of non-diabetes,with peptic ulcer detected by endoscopy.The two groups carried out gastroscopy as a routine examination and HP detection,analysis of two groups of clinical features,the site of ulcer HP-positive rate.A triple therapy with omeprazole 20mg bid,amoxicillin 1000mg bid and metronidazole 400mg bid was given to both groups HP infected patients for one week.Cure was defined as the absence of HP infection,assessed by 14C-urea breath test,4 weeks after completing anti-microbial therapy.Eradication rate calculated to compare differences between the two groups.Results Two groups of rhythmic pain,detection of gastric ulcer were significant difference（P0.05）,two groups of HP infection was no significant difference（P0.05）.T2DM and PU HP eradication rate of 61.5%（24/39）,significantly lower than the control Group eradication rate 88.0%（44/50）（P0.05）.Conclusion The clinical symptoms,ulcer location was different,and the HP infection rate was indifference between the two groups.The HP eradication rates by triple therapy,the T2DM group less than non-diabetic patients with PU.