慢性阻塞性肺疾病患者C反应蛋白与WBC、肺功能变化的临床研究

目的探讨慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)患者急性加重期与稳定期血清C反应蛋白(C-reactive protein,CRP)含量的变化及C反应蛋白与WBC、肺功能变化的临床意义。方法选择COPD患者68例,比较其治疗前后血清CRP水平及患者WBC总数和相应肺功能FEV1%、FEV1/FVC。结果 COPD急性加重期CRP为(48.8±13.2)mg/L,缓解期为(13.6±7.1)mg/L,差异有统计学意义。CRP与肺功能FEV1%、FEV1/FVC呈负相关。结论 C反应蛋白可作为COPD急性期感染的敏感指标,也可反映COPD感染治疗效果评价指标,亦可对COPD严重程度分级有一定指导意义。

Objective To investigate changes and clinical significance of serum C-reactive protein（CRP）and white blood cell（WBC）,lung function in the patients with acute exacerbation and remission of chronic obstractive pulmonary diseasse.Methods To select 68 patients and detect the changes of levels of CRP and WBC in serum,lung function FEV1%,FEV 1/FVC before and after treatment.To compare the changes of this index.Results The serum CRP level of COPD patients（48.8±13.2）mg/L was significantly higer than that of the patients at the stable stage（13.6±7.1）mg/L P0.01.There are negative correlation between CRP level and lung function FEV 1 %,FEV 1 /FVC.Conclusion The serum CRP level is a sensitive index in COPD patients with acute exacerbations,and it is also a good index to judge the early therapeutic efficacy in COPD patients with acute exacerbations.There are negative correlation between CRP level and lung function FEV 1 %,FEV 1 /FVC,which may guide diagnosis and staging of COPD.