砷对大鼠子代免疫功能影响的研究

The Effects of Exposure to Arsenic on the Immune Function in Rats' Offspring

为了解砷对大鼠子代免疫功能的影响，本研究采用了两代一窝繁殖试验的方法，观察了暴露于Ａｓ２Ｏ３大鼠子代免疫功能的变化。结果显示：在７５ｍｇ／Ｌ的高剂量Ａｓ２Ｏ３暴露组脾和胸腺的脏器系数明显低于对照组，血红蛋白和Ｔ淋巴细胞数显著降低，炭粒廓清速率的廓清指数和吞噬指数也明显低于对照组；而在低剂量和中剂量Ａｓ２Ｏ３暴露组其免疫学指标的改变则不明显。说明砷可以通过胎盘屏障。

The variances of immune function in rats' offspring whose parents were exposed to As 2O 3 were determined with the method of two generation-one nest reproduction to study the effects of arsenic exposure on the immune function of rats' offspring.The results showed that:some observed parameters of immune function,such as ratio of viscera of body weighy(spleen and thymus) ,hemoglbin,T lymphocytes,clearence index and phagocytic index in high concentration dose group (75 mg/L As 2O 3) were lower than those of controls.No significant variances in immune function indexes were observed in low (3 mg/L As 2O 3) and middle (15 mg/L As 2O 3) groups.It indicated that arsenic could pass through the placenta barrier and inhibit the immune function in rats' offspring especially under the high level exposure to arsenic