姜油对小鼠中枢神经系统的影响

Effect of Ginger (Zingiber officinale Roscoe) Oleoresin on Central Nervous System in Mice

目的:研究姜油对中枢神经系统的药理作用。方法:采用小鼠自主活动法、延长戊巴比妥钠睡眠时间法、抗硝酸士的宁致惊厥试验法及醋酸诱导扭体反应和热板致痛试验法,观察姜油的镇静催眠、抗惊厥和镇痛作用。结果:姜油能明显减少小鼠自发活动,延长戊巴比妥钠阈剂量睡眠时间,延长小鼠发生惊厥的潜伏期,大剂量能减少醋酸致小鼠扭体反应次数及抑制热板引起的疼痛。结论:姜油具有显著的中枢抑制作用。

Objective：To investigate the pharmacological action of ginger（Zingiber officinale Roscoe） oleoresin on central nervous system（CNS） . Method：：After i. g. administration of ginger oleoresin upon mice,the spontaneous activity of mice was determined,latency and sleeping time induced by pentobarbitol were measured,strychinine-induced convulsion was observed,acetic acid-induced writhing and hot plate-induced pain were tested. Results：Ginger oleoresin could significantly reduced mice locomotor activity,prolonged pentobarbital-induced sleep time of mice,delayed latency of convulsion induced by strychnine,reduced the number of writhing and stretching induced by the acetic acid and delayed latency of reaction to the thermal stimulus. Conclusion：Ginger oleoresin has significant inhibitory effect on CNS.