摘要
目的:制备黄芩苷水溶性栓剂并进行体外释放研究。方法:熔融法制备黄芩苷水溶性基质栓剂,采用体外溶出试验方法考察栓剂的释放特性。结果:制备的水溶性栓剂硬度、融变时限均符合要求。水溶性栓剂释药速度快,在40min时可达到最大释放,释放符合威布尔分布模型。结论:PEG4000∶PEG400为7∶6的黄芩苷栓剂型较优。
Objective：To prepare baicalin water-solubility suppository and to study and research vitro release of this suppository. Method：To adopt fusion method of preparation of the baicalin suppository and apply vitro dissolution testing to inspect release characteristics of this suppository. Result：Hardness and melt time limit of this suppository are conformed to requirement. this suppository release faster,achieve maximum releasing within 40 minutes and it＇s releasing consistent with Weibull Distribution Model. Conclusion：This preparation method was easy to operate;the quality was stable and controllable. The excellent ratio of PEG 4000/PEG 400 is 7/6.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第8期1-3,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
武警医学院科研课题资助项目(WY200817)
关键词
黄芩苷
栓剂
聚乙二醇
体外释放
baicalin
Suppository
Polyethylene glycol
vitro release
