紫癜颗粒对免疫性血小板减少性紫癜模型小鼠外周血白介素-11、转化生长因子β_1的影响

Effects of Purpura Granules on Levels of Interleukin-11 and Transforming Growth Factor-beta_1 in Peripheral Blood of Mouse Model with Idiopathic Thrombocytopenic Purpura

目的:通过观察免疫性血小板减少性紫癜(ITP)模型小鼠外周血白介素-11(IL-11)、转化生长因子(TGF-β1)含量的变化,探讨IL-11,TGF-β1含量变化与ITP发病之间的内在联系。方法:采用酶联免疫方法检测ITP模型小鼠外周血IL-11,TGF-β1含量变化。结果:模型组小鼠外周血IL-11,TGF-β1含量明显升高,均有统计学意义(P<0.05)。结论:调节巨核细胞的正性作用因子IL-11与负性作用因子TGF-β1参与了ITP的发病过程并发挥重要作用,紫癜颗粒通过调控外周血IL-11,TGF-β1的含量变化而达到有效治疗ITP的目的。

Objective：To explore the relationship between the changes in interleukin-11 （ IL-11） and transforming growth factor-beta1 （ TGF-β1 ） and occurrence of idiopathic thrombocytopenic purpura （ ITP ） by investigating content of IL-11 and TGF-β1in peripheral blood of the mouse model with ITP.Method：Contents of IL-11 and TGF-β1in peripheral blood of the mouse model with ITP were measured by ELISA.Result：Contents of IL-11 and TGF-β1in peripheral blood of model group increased significantly,and it was statistically significant（P〈0.05）.Conclusion：IL-11 and TGF-β1 play an important role in occurrence of ITP,and Purpura Granules can cure ITP effectively by regulating contents of IL-11 and TGF-β1in peripheral blood.