菊黄上清含片的抗炎解热镇痛作用

Study on the anti-inflammatory anti-febric and analgesic effect of Juhuangshangqing buccal lozenge

目的:研究菊黄上清含片的抗炎、解热、镇痛作用。方法:通过角叉菜胶所致大鼠和小鼠足肿胀、二甲苯所致小鼠耳肿胀、羧甲基纤维素钠所致小鼠腹腔白细胞游走实验观察其抗炎作用;通过干酵母所致大鼠发热和内毒素所致家兔发热实验观察其解热作用;通过热板法和醋酸扭体法观察其镇痛作用。结果:抗炎实验表明,菊黄上清含片可明显减轻角叉菜胶所致的大鼠和小鼠足肿胀,可使二甲苯所致的小鼠耳肿胀程度减轻,高、中剂量组可降低羧甲基纤维素钠所致小鼠腹腔白细胞游走。解热实验表明,菊黄上清含片高、中剂量组均能明显抑制干酵母所致大鼠和内毒素所致家兔体温升高。镇痛实验表明,菊黄上清含片均能提高小鼠的痛阈值,有效地减少醋酸所致小鼠的扭体次数,但与对照组比较差异无显著性(P>0.05)。结论:菊黄上清含片具有良好的抗炎、解热作用。

OBJECTIVE To investigate the anti-inflammatory, anti-febric and analgesic effect of Juhuangshangqing buccal lozenge. METHODS Anti-inflammatory effects were studied by the models of paw edema induced by carrageen in mice and rats, ear swelling induced by xylene in mice and CMC Na inducing leucocyte-strolling in the mice; fever in rats induced by dry yeast and fever in rabbits induced by endotoxin were used to study the anti-febric effects. The pain models were established by acetic acid and hot plate in mice. RESULTS The drug could obviously inhibit the paw edema induced by carrageen in mice and rats and the ear swelling induced by xylene in mice, and decrease the leucocyte-strolling in mice with high,middle dosage. The drug could obviously lower the high temperature of fever model in mice and rabbits; The drug could decrease the times of mice＇ s writhing response and increase the threshold value of pain, but there was no significant difference comparing with eontral group（P〉0. 05）. CONCLUSION Juhuangshangqing buccal lozenge have anti-inflammatory and anti-febric effects.