神经生长因子在脑膜瘤细胞核中的表达及其临床意义

Nuclear expression of nerve growth factor in meningioma and its clinical significance

目的 探讨神经生长因子（NGF）在脑膜瘤中的表达及其临床意义.方法 对56例脑膜瘤切片进行NGF、孕激素受体（PR）、Ki67免疫组织化学染色,并随访患者脑膜瘤复发情况.结果 脑膜瘤中NGF核阳性率为41.1%,高于Ki67阳性率35.7%（P〉0.05）.PR阳性率为印.7%.NGF核阳性率与Ki67阳性率呈正相关（r=0.741,P〈0.01）,与PR阳性率呈负相关（r=-0.59,P〈0.01）.NGF核阳性组患者中位复发时间（36.000±2.484）个月明显短于NGF核阴性组（59.000±2.295）个月（P〈0.01）.结论 NGF核阳性率可以作为脑膜瘤细胞增殖活性及预后判断指标.

Objective To investigate the expression of nerve growth factor （NGF） in meningioma and its biological significance. Methods Fifty-six cases of meningioma sections were immunohistochemi-cally stained with NGF, PR, Ki67 antibodies. Corresponding patients were followed up for recurrence of meningioma. Results NGF nuclear positive rate （41. 1% ） was higher than Ki67 positive rate （35. 7% ） （P〉0.05 ）. PR positive rate was 60. 7%. NGF nuclear positive rate was positively correlated with Ki67 positive rate （r =0. 741 ,P〈0. 01）, while negatively with PR positive rate （r = -0. 59,P〈0.01）. The median relapse time of NGF nuclear positive patients was 36. 000 ± 2. 484 months, which was significantly shorter than that of NGF nuclear negative group （59.000 ± 2. 295 months） （P 〈0.01 ）. Conclusion NGF nuclear positive rate can be used as an indicator for proliferation and prognosis of meningioma.