正交设计法优选天山雪莲凝胶剂基质处方

Formulation optimization of gel matrix of Saussurea involucrate by orthogonal design

目的:优选天山雪莲凝胶剂基质处方。方法:采用正交设计法,以凝胶剂基质在室温下的黏度和屈服值、在体表温度下的黏度和屈服值、触变性为指标,优化处方中卡波姆940、氮酮、丙二醇和无水乙醇的用量。结果:天山雪莲凝胶剂基质处方最佳配比为卡波姆-氮酮-丙二醇-无水乙醇(2.0∶2.0∶15.0∶30.0)。结论:采用该优选处方制备的天山雪莲凝胶剂均匀透明,黏度适中,触变性良好。

Objective： To optimize the formulation of gel matrix of Saussurea involucrate.Method： The formulation of gel containing carbopol,azone,trimethylene glycol and alcohol was optimized by orthogonal design with evaluation indexes such as consistency in room temperature, consistency of average temperature of skin,yield value and rheopexy in room temperature.Result： The optimal proportion of matrix components was made from carbopol-azone-trimethylene glycol-absolute alcohol（2.0∶2.0∶15.0∶30.0）.Conclusion： The optimal formulation of S.involucrate gel based the optimal formulation is well-distributed and transparent,it has proper consistency and well rheopexy.