摘要
目的:优选天山雪莲凝胶剂基质处方。方法:采用正交设计法,以凝胶剂基质在室温下的黏度和屈服值、在体表温度下的黏度和屈服值、触变性为指标,优化处方中卡波姆940、氮酮、丙二醇和无水乙醇的用量。结果:天山雪莲凝胶剂基质处方最佳配比为卡波姆-氮酮-丙二醇-无水乙醇(2.0∶2.0∶15.0∶30.0)。结论:采用该优选处方制备的天山雪莲凝胶剂均匀透明,黏度适中,触变性良好。
Objective: To optimize the formulation of gel matrix of Saussurea involucrate.Method: The formulation of gel containing carbopol,azone,trimethylene glycol and alcohol was optimized by orthogonal design with evaluation indexes such as consistency in room temperature, consistency of average temperature of skin,yield value and rheopexy in room temperature.Result: The optimal proportion of matrix components was made from carbopol-azone-trimethylene glycol-absolute alcohol(2.0∶2.0∶15.0∶30.0).Conclusion: The optimal formulation of S.involucrate gel based the optimal formulation is well-distributed and transparent,it has proper consistency and well rheopexy.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第14期1803-1805,共3页
China Journal of Chinese Materia Medica
基金
石河子大学科学技术研究发展计划项目(重大攻关专项)(gxji2008-zdgg05)
自治区科技支疆计划项目(201091156)
关键词
天山雪莲
凝胶剂
基质处方
Saussurea involucrate
gel
matrix formulation