模糊综合评价法评价促透剂对茶碱促透效果的研究

Promoting effect for transdermal enhancers on theophylline with fuzzy comprehensive evaluation method

目的探讨模糊综合评价法在促透剂促透效果综合评价中的运用。方法以茶碱为模型药物,氮酮为阳性促透剂,研究中药促透剂薄荷醇、樟脑、丁香油、荆芥油、广藿香油对模型药物在离体SD大鼠背部皮肤上的透皮行为的影响,计算渗透系数、稳态流量、滞后时间、增渗倍数,运用模糊综合评价法对促透效果进行综合评价。结果对茶碱的促渗作用,1%丁香油表现为优,1%氮酮表现为良,1%薄荷醇、1%樟脑、1%广藿香、1%荆芥油表现为中。结论模糊综合评价法可客观地评价促透剂的促透效果。

Objective To investigate the utilization of fuzzy comprehensive eva-luation method for eva-luatingthe promoting effect of transdermal enhancer. Methods Taking theophylline as drug model, Azone as positive transdermal enhancer, the penetrating srates, teady fluxes, lag time, and enhancement ratio were calculated. Menthol camphor, dove oil, Schizonepeta temuifolia oil, and Pogostemon cablin oil using on the back skin of SD rat were observed on the equipment of percutaneous absorption in vitro. The promotion of transdermal enhancers was evaluated by fuzzy comprehensive evaluation method. Results As for promoting effect on theophylline, 1% dove oil was the best and 1% Azone ranked behind, 1% menthol, 1% camphor, 1% P. cablin oil, and 1% S. temuifolia oil were medium. Conclusion Fuzzy assessment method could be used to evaluate the promoting effect of transdermal enhancers objectively.