黄豆苷元自微乳化半固体骨架胶囊的制备

Preparation of self-microemulsifying semi-solid matrix hard capsules of daidzein

目的:考察黄豆苷元自微乳化半固体骨架胶囊的处方。方法:通过溶解度实验、处方配伍实验和伪三相图的绘制,以自乳化时间和效果为指标,筛选油相、表面活性剂、助表面活性剂、半固体载体的最佳搭配和处方配比,并制备黄豆苷元自微乳化半固体骨架胶囊。结果:黄豆苷元自微乳化半固体骨架胶囊处方中黄豆苷元(1.5%),油相为M-812N(20%),表面活性剂为聚山梨酯80(Tween 80)+RH 40(1∶1,45%),助表面活性剂为Transcutol(20%),半固体载体为S-40(15%)。该处方所形成的微乳平均粒径为39.6 nm。结论:可按照最佳处方组成制备黄豆苷元自微乳化半固体骨架释药系统。

Objective： To develope the formulation of daidzein self-microemulsifying hard capsules drug delivery system.Methods： The optimal formulations of daidzein self-microemulsifying hard capsules were screened by solubility experiments,compatibility tests and pseudo-ternary phase diagrams,with the time of formulating microemulsion and the efficient of microemulsifying.The daidzein self-microemulsifying hard capsules were prepared.Results： The optimal daidzein self-microemulsifying hard capsules were composed of daidzein（1.5%）,M-812N（20%）,Tween 80＋RH 40（1∶1,45%）,Transcutol（20%）,and S-40（15%）.Microemulsion droplets with a mean droplet size of 39.6 nm were formed by using this formulation.Conclusion： Daidzein self-microemulsifying hard capsules can be prepared based on the optimal formulations.