摘要
[目的]评价动脉灌注化疗对ⅢB期宫颈癌的疗效。[方法]以动脉插管化疗及腔内镭疗各 1个疗程治 76例ⅢB期宫颈癌;对照组是同期标准放疗的ⅢB期患者; 1组用X线体外放疗54例,2组体外放疗用60Co有70例,全部患者随诊10年以上。[结果]三组患者的10年生存率分别是:研究组为61.9%,对照1组是37.0%(P=0.25),对照2组有44.3%(P=0.28)。研究组患者治疗后无放射性直肠炎等并发症。 1例经1个疗程化疗的ⅡB期宫颈癌,治后无癌生存18年。[结论]合理的化疗加腔内放疗可以治愈ⅢB期宫颈癌,并减少放疗并发症。
Purpose] To evaluate the effect of intra-arterial chemotherapy on cervix carcinoma at stage ⅢB. [Methods] Seventy-six patients with cervix cancer ⅢB were treated by intra-arterial chemotherapy followed by radiation therapy as the study group. Concurrently 54 cases (radium and X-ray) and 70 cases (radium and 60Co) were treated with standard radiation as the control group. All cases had 10-year follow-up data. [ Results] Ten-year survival rate: 61.9% in the study group, 37.0% in the control group I (P = 0.25), and 44.3% in the control group Ⅱ (P = 0.28). Cases in study group had no radiation complication with rectitis. One patient with cervix cancer at stage Ⅱ B treated by one course of intra-arterial chemotherapy without radiation remained free of disease for 18 years. [Conclusion] If intra-arterial chemotherapy is designed rationally and combined with intracavitary radiation, it can cure patients with cervical cancer at stage ⅢB, and also it may decrease the radiation complications.
关键词
动脉化疗
宫颈肿瘤
生存率
治疗
Intra-arterial chemotherapy Cervix neoplasms Survival rate