宫颈癌动脉化疗78例远期疗效

The Effect of Intra-arterial Chemotherapy for Cervix Carcinoma

［目的］评价动脉灌注化疗对ⅢＢ期宫颈癌的疗效。［方法］以动脉插管化疗及腔内镭疗各 １个疗程治 ７６例ⅢＢ期宫颈癌；对照组是同期标准放疗的ⅢＢ期患者； １组用Ｘ线体外放疗５４例，２组体外放疗用６０Ｃｏ有７０例，全部患者随诊１０年以上。［结果］三组患者的１０年生存率分别是：研究组为６１．９％，对照１组是３７．０％（Ｐ＝０．２５），对照２组有４４．３％（Ｐ＝０．２８）。研究组患者治疗后无放射性直肠炎等并发症。 １例经１个疗程化疗的ⅡＢ期宫颈癌，治后无癌生存１８年。［结论］合理的化疗加腔内放疗可以治愈ⅢＢ期宫颈癌，并减少放疗并发症。

Purpose] To evaluate the effect of intra-arterial chemotherapy on cervix carcinoma at stage ⅢB. [Methods] Seventy-six patients with cervix cancer ⅢB were treated by intra-arterial chemotherapy followed by radiation therapy as the study group. Concurrently 54 cases (radium and X-ray) and 70 cases (radium and 60Co) were treated with standard radiation as the control group. All cases had 10-year follow-up data. [ Results] Ten-year survival rate: 61.9% in the study group, 37.0% in the control group I (P = 0.25), and 44.3% in the control group Ⅱ (P = 0.28). Cases in study group had no radiation complication with rectitis. One patient with cervix cancer at stage Ⅱ B treated by one course of intra-arterial chemotherapy without radiation remained free of disease for 18 years. [Conclusion] If intra-arterial chemotherapy is designed rationally and combined with intracavitary radiation, it can cure patients with cervical cancer at stage ⅢB, and also it may decrease the radiation complications.