摘要
［目的］研究大脑实质内孤立性浆细胞瘤。［方法］采用光镜、组织化学和免疫组化染色对２例大脑实质内孤立性浆细胞瘤进行观察，并文献复习。［结果］瘤细胞较单一，为不成熟及接近成熟的浆细胞，呈瘤性增生。甲基－哌络宁（ＭＧＰ）染色，瘤细胞胞浆呈鲜红色。血管壁及瘤组织间有对刚果红染色阳性的淀粉样物质。瘤细胞示单克隆性轻链ｋａｐｐａ阳性。［结论］大脑实质内孤立性浆细胞瘤是一种十分罕见肿瘤，诊断时应排除多发性骨髓瘤侵犯脑实质。此瘤诊断依靠光镜、组织化学和免疫组化染色、临床实验室资料，才能作出确切诊断。
Purpose] To report two cases uncommon Intracerebral solitary plasmacytoma (ISP). [Methods] Two cases of ISP were pathologically observed by light microscopy, histochemical staining and immunohistochemical staining. [Results] Microscopically, these two tumors were all consisting of sheets of more well - differentiated plasma cells with round nuclei contain coarse blocks of chromatin at the periphery. Histochemistry, methyl green pyronin staining showed bright red colour in the cytoplasms of tumors cells while green colour in the nuclei. Amyloid deposits were observed extracelluar spaces and in the walls of tumor vessels. Immunhistochemistry, tumor cells were positive for kappa and negative for lambda. [Conclusion] Intracerebral solitary plasmacytoma is a uncommon tumor .A definite diagnosis must depend on microscopical examination, histochemical staining, immunohistochemical technique and laboratorial, clinical data etc .The possibility of multiple myeloma of the base of skull invading the intracerebrum should be ruled out.
