食管癌放射治疗联合化疗疗效观察

Observation of the efficacy of chemotherapy combined with radiotherapy for esophageal cancer

目的:观察食管癌放射治疗联合DF方案化疗的临床疗效和毒副反应。方法:将符合入组条件的92例食管癌患者随机分为单纯放疗组(46例)和放化组(46例)。单纯放疗组采用6MVX直线加速器常规照射,每次1.8-2Gy,每周5次,照射剂量为60～70Gy。放化组外照射同常规放疗组,放射治疗当日开始采用DF方案化疗:氟尿嘧啶(5-FU)500mg/d,d1-5;顺铂(DDP)20mg/d,d1-5,28天一个疗程,每例至少化疗2疗程后评价疗效,共用2～4疗程。结果:放化组和单放组缓解率分别为82.6%和58.7%(P<0.05)。结论:放射治疗联合DF方案化疗,疗效优于单纯放疗,毒副反应可以耐受,是治疗食管癌的有效方法。

Objective：To observe the results and side effects of chemotherapy with DF combined with radiotherapy in treatment of esophageal cancer.Methods：A prospective randomized trial on chemotherapy （C） with DF（Cisplatin ＋fluorouracil）combined with radiotherapy（R） for esophageal cancer was carried out in 92 patients.The patients were randomized into combined group （R＋C,46 patients） or radiotherapy alone group （R,46 patients）.6MV photon was used for all patients,each 1.82Gy,5 times a week,irradiation dose 6070Gy.combined group with conventional external beam radiotherapy,radiation therapy began the day with DF regimen： fluorouracil （5FU） 500mg / d,d15.Cisplatin （DDP） 20mg/d.d15,a course of treatment every 28 days,Eifficacy and toxicity were evaluated after two cycles（range：2~4）.Results：The combined group and the radiotherapy alone group remission rates were 82.6% and 58.7% （P 0.05）.Conclusion：The efficacy of chemotherapy（C） with DF combined with radiotherapy is superior to radiotherapy alone,toxicity can be tolerated,and may be a therapeutic alternative for esophageal cancer.