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结缔组织生长因子的研究进展 被引量:5

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摘要 结缔组织生长因子是一种富含半胱氨酸的分泌多肽,与细胞的生长、增生、分泌有关。它在动脉粥样硬化斑块、纤维化性皮肤病以及肿瘤纤维基质中均有高表达,而且刺激成纤维细胞生长、基质产生、肉芽组织形成。其与β转化生长因子。
作者 韵慧枫
出处 《国外医学(生理病理科学与临床分册)》 1999年第1期60-61,共2页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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  • 1刘小菁,吴红斌,刘芳,黄明慧,强鸥,黄颂敏.肿瘤坏死因子α对肝星状细胞表达结缔组织生长因子的影响[J].中华肝脏病杂志,2001,9(S1):15-17. 被引量:8
  • 2黄海长,李深,杨敏,闵亚丽,李惊子,王海燕.低密度脂蛋白受体相关蛋白在肾间质纤维化模型中的表达[J].中国病理生理杂志,2004,20(8):1345-1348. 被引量:3
  • 3Yokoi H, Sugawara A, Mukoyama M, et al. Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis[J]. Am J Kidney Dis, 2001,38(4Suppl 1): S134-138
  • 4Suzuma K,Naruse K,Suzuma I,et al.Vascular Endothelial Growth Factor Induces Expression of Connective Tissue Growth Factor via KDR,Flt1,and Phosphatidylinositol 3-Kinase-Akt-dependent Pathways in Retinal Vascular Cells[J].J Biol Chem,2000,275:40725-40731.
  • 5Murphy M,Godson C,Connon S,et al.Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cell[J].J Biol Chem,1999,274:5830-5834.
  • 6Uemura T,Chandrashekhar R,Gandhi.Inhibition of DNA synthesis in cultured hepatocytes by endotoxin-conditioned medium of activated stellate cells is transforming growth factor-β and nitric oxide-independent[J].Brit.J of Pharmacology,2001,133:1125-1133.
  • 7Paradis V,Dargere D,Vidaud M,et al.Expression of connective tissue growth factor in experimental ratand human liver fibrosis[J].Hepatology,1999,30:968-976.
  • 8Lasky JA,Ortiz LA,Tonthat B,et al.Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis[J].Am J Physiol,1998,275:L365-L371.
  • 9Williams EJ,Gaca MD,Brigstock DR,et al.Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells[J].J Hepatol,2000,32:745-761.
  • 10Hishikawa K,Oemar BS,and Nakaki T.Static Pressure Regulates Connective Tissue Growth Factor Expression in Human Messangial Cell[J].J.Biol.Chem,2001,276:16797-16803.

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