摘要
目的研究小剂量ｒｈＧ－ＣＳＦ对急性白血病（ＡＬ）联合化疗后白细胞减少的治疗作用。方法对ＡＬ化疗后外周血白细胞显著减少，中性分叶核绝对值＜０．５×１０９／Ｌ，且伴有发热和感染者，给予ｒｈＧ－ＣＳＦ７５μｇ／ｄ，皮下注射，共３ｄ～７ｄ。同时给予抗感染治疗。结果小剂量ｒｈＧ－ＣＳＦ治疗后，白细胞在短期内升高，有效率达８７．３％，显著高于对照组（Ｐ＜０．０１）。且ｒｈＧ－ＣＳＦ组感染的持续时间较对照组短（Ｐ＜０．０１）。结论小剂量ｒｈＧ－ＣＳＦ能有效地促进ＡＬ化疗后外周血白细胞的恢复，有利于及时控制感染。
Objective To study the role of low dose G CSF for the leukocytepenia in acute leukemia chemotherapy. Methods Acute leukemia patients of leukocytopenia in chemotherapy asbolute neutrophil count(≤0.5×10 9/L), complication of fever and infection were treated by low dose G CSF (75 μg/d 3～5 days). Results Low dose G CSF could increase granulocyte rapidly. The effective rate was 87.3% significantly higher than that in controls( P <0.01). The total duration of infections was significantly reduced from 9.8 to 4.8 days per patient( P <0.01). Conclusion Low dose G CSF administered in hypodermic injection between chemotherapy courses markedly increased granulocyte and shortened duration of infections.
出处
《白血病》
1999年第1期14-15,共2页
