亚小型及其它巨核细胞在慢粒中诊断价值的探讨

DIAGNOSTIC VALUE OF SUB SMALL AND OTHER MEGAKERYOCYTIES IN CHRONIC GRANULOCYTIC LEUKEMIA

目的探讨亚小型、正常型及小型、微型巨核细胞在慢粒的诊断价值。方法采用骨髓细胞形态学观察，对４０例慢粒慢性期初诊骨髓的亚小型、正常型巨核细胞（个／片）计数分类和小及微型巨核细胞在片尾计数１０００个有核细胞中的数量及其分类，同时对１８例正常骨髓用以上方法计数分类作为对照组，并进行统计学处理分析。结果亚小巨核细胞及其他巨核细胞增生是慢粒主要病变特征之一，特别是亚小型巨核细胞对慢粒具有极其显著性意义。结论亚小型。

Objective To discuss diagnostic value of sub small type,normal type and small and micro megakaryocyties in chronic granulocytic leukemia (CGL). Method Investigating 40 cases of CGL by employing bone marrow cell morphology observation,counting and classification of sub small and normal megakaryocyties of the preliminary stages of CGL and counting and classification of small and micro megakaryocyties which have 1,000 nucleared bone marrow cells. The same method is applied to a comparison group of 18 cased of normal marrow. Results The growth of sub small megakaryocyties and other megakaryocyties is a main feature of pathological changes of CGL. Sub small megakaryocyties in oparticular have significant statistical meaning. Conclusion Sub small,normal and small (micro) megakaryocyties are important for morphologic diagnosis and distinguishing diagnosis of CGL.