肿瘤浸润淋巴细胞治疗老年人恶性胸水的疗效分析

An analysis of the therapeutic effect of tumour infiltrating lymphocytes on malignant pleural effusion in aged

目的探讨肿瘤浸润淋巴细胞（ＴＩＬ）治疗老年癌症患者恶性胸水的有效率。方法应用癌症患者自体胸水的ＴＩＬ培养、扩增后产物经胸腔内输注治疗２１例老年人恶性胸水，每隔日１次，至少４次。结果２１例经治疗后，胸水中淋巴细胞增加，肿瘤细胞逐渐减少，胸腔积液逐渐吸收，１个月后１９例达完全缓解和部分缓解，有效率为９０．５％。结论自体胸水ＴＩＬ可治疗恶性胸水，同时可提高老年癌症患者的免疫功能，对机体无毒副作用。

Objective To study the therapeutic effect of tumour infiltrating lymphocytes (TIL) on malignant pleural effusion in aged cancer patients. Methods TIL cultured and amplified product of cancer patient's own malignant pleural effusion was used for treatment in aged cancer patients by intrapleural injection once every other day for at least four times. Results In 21 cases treated, lymphocytes in pleural effusion increased, while tumour cells gradually decreased, and pleural effusion gradually absorbed. After 1 month 19 cases were effective (90 5%). Conclusions Auto pleural effusion tumour infiltrating lymphocytes might be effective for malignant pleural effusion.