重症肺炎支原体肺炎肺泡灌洗液中TNF-α、IL-6、IL-8、IL-10水平观察

The Study of BALF TNF-α,IL-6,IL-8,IL-10 Concentration in Critically Ⅲ Pneumonia Mycoplasma Pneumonia Patients

目的检测重症肺炎支原体肺炎患者支气管肺泡灌洗液(bronchial tube pul monary alveolus syringe fluid,BALF)中肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、白细胞介素-8(In-terleukin-8,IL-8)白细胞介素-10(Interleukin-10,IL-10)浓度,探讨其临床意义。方法收住ICU的重症肺炎支原体肺炎患者36例,其CPIS评分>6分为CPIS高分组共15例,CPIS评分<6分为CPIS低分组共21例;正常对照组24例。取支气管肺泡灌洗液检测TNF-α、IL-6、IL-8、IL-10水平。结果重症肺炎支原体肺炎无论CPIS高分组和CPIS低分组支气管肺泡灌洗液中TNF-α、IL-6、IL-8、IL-10水平明显高于对照组,差异有统计学意义(P<0.01),CPIS高分组TNF-α、IL-6、IL-8水平高于CPIS低分组,差异有统计学意义(P<0.01),CPIS高分组IL-10水平稍高于CPIS低分组,差异无统计学意义(P>0.05)。2组治疗后恢复期TNF-α、IL-6、IL-8、IL-10水平均明显下降(P<0.01)。结论 TNF-α、IL-6、IL-8、IL-10在重症肺炎的发生发展中起重要作用,是重症肺炎支原体肺炎诊断的重要因素之一。利用支气管肺泡灌洗液检测TNF-α、IL-6、IL-8、IL-10水平变化对临床诊断治疗及预后有一定的临床价值。

Objective To investigate the concentration changes of BALF TNF-α,IL-6,IL-8,IL-10 in the patients with critically ill mycoplasma pneumonia pneumonia and to probe the clinical significance.Methods The critically ill mycoplasma pneumonia pneumonia 36 cases were collected and divided into the follow groups：total 15 cases with CPIS Mark） 6 points;CPIS high grade;total 21 cases with CPIS low grade,and 24 normal cases.The levels of BALFin TNF-α、IL-6、IL-8、IL-10 were detected.Results The levels of TNF-α、IL-6、IL-8、IL-10 in bronchial tube pulmonary alveolus syringe fluid were obviously higher no matter in CPIS high grade and in CPIS low grade,compared to the normal cases which the statistics has clear divergences（P〈0.01）.The divergent statistics also demonstrated the level in CPIS high gradewais slightly higher than the CPIS low grade.There did not have been any clearly divergence in CPIS high group slightly higher than the CPIS low group（P〉0.05） the level of TNF-α、IL-6、IL-8、IL-10 of 2 group totally desends in the recovering period after the treatment（P〈0.01）.Conclusion TNF-α、IL-6、IL-8、and IL-10 play a significant role in the development of Mycoplasma pneumonia.Meanwhile they are important issues in diagnosis of Mycoplasma pneumonia.There exists specific clinical significance in clinical diagnose and precaution to investigate the investigate the concentration changing of TNF-α,IL-6,IL-8,IL-10 with bronchial tube pulmonary alveolus syringe fluid.