血府逐淤汤联合川芎嗪治疗椎-基底动脉供血不足性眩晕的临床研究

Clinical study on treating vertigo of vertebrobasilar insufficiency with the combination of tetramethylpyrazine with xuehuzhuyu decoction

目的观察血府逐淤汤联合川芎嗪治疗椎-基底动脉供血不足性眩晕的临床疗效。方法将诊断为椎-基底动脉供血不足性眩晕患者120例随机分为观察组与对照组,观察组给予口服血府逐淤汤和静脉滴注川芎嗪120 mg联合治疗,对照组给予川芎嗪120 mg治疗。对比观察其临床疗效及经颅多普勒超声(TCD)、血液流变学改变情况。结果观察组在临床疗效、TCD、血液流变学改善方面均明显优于对照组(P<0.01)。结论血府逐淤汤联合川芎嗪治疗椎-基底动脉供血不足性眩晕疗效满意。

Objective To observe the efficacy of tetramethylpyrazine combined with xuehuzhuyu decoction in the treatment of vertebrobasilar insufficiency（VBI）.Methods Among the 120 VBI patients,60 were treated by of tetramethylpyrazine combined with xuehuzhuyu decoction,the others were treated by tetramethylpyrazine only.The clinical efficacy,hemorrheology,tanscranial doppler（TCD） were measured at one day before and after treatment for each case.Results A improvement of overall efficacy was observed in tetramethylpyrazine combined with xuehuzhuyu decoction group compared with tetramethylpyrazine group（93.33% vs 70.00% P0.05）.Conclusion The combination of tetramethylpyrazine combined with xuehuzhuyu decoction was proved to be effective than that of tetramethylpyrazine in the treatment of VBI.