硫酸氢氯吡格雷治疗不稳定型心绞痛疗效观察被引量：2

下载PDF

导出

摘要目的观察硫酸氢氯吡格雷治疗不稳定型心绞痛(UAP)的临床疗效。方法将130例UAP患者分为常规治疗(对照组)60例和硫酸氯吡格雷组(治疗组)70例。治疗组在常规治疗基础上加用硫酸氯吡格雷治疗1个月,对照组应用阿斯匹林、β—阻滞剂、硝酸酯类药物和/或钙拮抗剂、低分子肝素。观察用药前后两组心绞痛症状改善程度、心电图、血流变学、血压及心率变化。结果治疗1个月后,治疗组心绞痛症状改善总有效率达97.14%,高于对照组的60%(P<0.01);治疗组心电图ST段缺血改变比较及血流变学各项指标比较均优于对照组(P<0.01);治疗组对心率血压影响与对照组比较,无统计学意义(P>0.05),无出血等不良反应。结论硫酸氯吡格雷治疗UAP疗效显著。

作者寇丽娜毛丹叶淑芬

机构地区宁夏吴忠市人民医院

出处《宁夏医学杂志》 CAS 2010年第7期621-622,共2页 Ningxia Medical Journal

关键词硫酸氢氯吡格雷不稳定型心绞痛血流变学

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献5

1华先平,孔祥辉,杜令,管高峰,王琳.氯吡格雷对兔动脉粥样硬化基质金属蛋白酶-9及血管壁核因子-κB表达的影响[J].临床心血管病杂志,2007,23(6):464-467. 被引量：6
2柯元南,陈纪林.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2007,35(4):295-304. 被引量：2136
3韩雅玲,李成洋,李毅,康建,闫承惠.急性冠状动脉综合征冠状动脉支架术后应用他汀类药物对氯吡格雷抗血小板作用无影响[J].中华心血管病杂志,2007,35(9):788-792. 被引量：19
4李瑞杰.解读不稳定型心绞痛和ST段不抬高心肌梗死治疗指南[J].中国医刊,2004,39(7):14-17. 被引量：2
5高展.氯吡格雷在动脉粥样硬化血栓形成性疾病中的应用.医心评论,2006,10:9-12.

二级参考文献48

1李小鹰.阿司匹林在动脉硬化性心血管疾病中的临床应用:中国专家共识(2005)[J].中华心血管病杂志,2006,34(3):281-284. 被引量：193
2Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction-summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines(Committee on the Management of Patients With Unstable Angina). J Am Coll Cardiol,2002, 40(7) :1366-1374.
3Bertrand ME, Simoons ML, Fox KA, et al. Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J,2002,23 ( 23 ) : 1809 -1840.
4Erhardt L, Herlitz J, Bossaert L, et al. Task force on the management of chest pain. Eur Heart J, 2002, 23 ( 15 ) : 1153-1176.
5CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet, 1996, 348(9038) :1329-1339.
6Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med, 2001 , 345 ( 7 ) :494-502.
7Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet, 2001, 358(9281):527-533.
8Simoons ML, GUSTO IV-ACS Investigators. Effect of glycopmtein Ⅱb/Ⅲa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation:the GUSTO IV-ACS randomised trial. Lancet, 2001,357(9272) :1915-1924.
9Platlat Receptor Inhibitor in Ischemic Syndrome Management(PRISM) study investigator. A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. Platelet Receptor Inhibition in Ischemic Syndrome Management ( PRISM )Study Investigators. N Engl J Med, 1998, 338(21 ) :1498-1505.
10Platlat Receptor Inhibitor in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms(PRISM-PLUS) study investigator. Inhibition of the platelet giycoprotein Ⅱb/Ⅲa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) Study Investigators. N Engl J Med,1998, 338(21) :1488-1497.