Ⅲ期卵巢上皮性癌手术彻底性对预后的影响

Stage Ⅲ epithelial ovarlan cancer The prognosis of complete tumor excision and residual lesions of less than 2cm.

目的通过分析接受肿瘤细胞减灭术的临床Ⅲ期卵巢上皮性癌患者的手术切净与基本切净的５年存活率，探讨残余肿瘤的大小对其预后的影响。方法自１９８２年１月至１９９５年６月，共收治临床Ⅲ期卵巢上皮癌１８６例，对其进行回顾性研究，并对结果进行统计学处理。结果４３例肿瘤切除干净者，其５年存活率为３２５％；７６例肿瘤基本切净者的５年存活率为２１４％（Ｐ＜００１）。基本切净者，３２例术后１年内化疗≥６疗程的５年存活率为２５２％，４４例术后１年内化疗＜６疗程的５年存活率为２０１％。结论肿瘤切净者的５年存活率高于肿瘤基本切净者的５年存活率。术后１年内化疗≥６疗程可提高基本切净者的５年存活率。

Objective To study the 5-year survival rate of complete tumor excision and residual lesions ≤2cm in stage Ⅲ epithelial ovarian cancer,and observe the effect on survival of debulking surgery.Methods 186 cases of stage Ⅲ epithelial ovarian cancer who received treatment in PUMC hospital from Jan,1982 to June,1995 were analyzed retrospectively.Results The 5-year survival rate of 43 cases(36 1%)having complete tumor excision was 32 5%,while for 76 cases (63 9%)having residual lesions≤2cm was 21 4%(P<0 01).Of the cases with residual lesions ≤2cm,the 5-year survival rate of 32 cases having chemotherapy ≥6 cycles in one year was 25.2%,while 44 cases having chemotherapy <6 cycles in one year was 20 1%.Conclusions The 5-ycar survival rate of stage Ⅲ epithelial ovarian cancer having complete tumor excision was higher than that with residual lesions ≤2cm.Of the cases with residual lesions ≤2cm,the patients having chemotherapy ≥6 cycles in one year could raise their 5-year survival rate \ \