摘要
The phosphatidylinositol 3-kinase/Akt serine/threonine kinase system regulates multiple cellular processesthrough the phosphorylation of a great number of downstream substrates and has been recognized as an important pathway for signal transduction, and in cancer invasion and metastasis.1 Although it is accepted that Akt promotes the metastasis of human malignant tumors, the mechanisms of Akt function to promote cell migration remains to be elucidated. Girdin,
The phosphatidylinositol 3-kinase/Akt serine/threonine kinase system regulates multiple cellular processesthrough the phosphorylation of a great number of downstream substrates and has been recognized as an important pathway for signal transduction, and in cancer invasion and metastasis.1 Although it is accepted that Akt promotes the metastasis of human malignant tumors, the mechanisms of Akt function to promote cell migration remains to be elucidated. Girdin,
