金属基质蛋白酶9对急性脑梗死病情进展预测意义的研究

Prediction significance of matrix metalloproteinase-9 in the progress of acute cerebral infarction

目的探讨金属基质蛋白酶9(MMP-9)对急性脑梗死病情进展的预测作用。方法收集40例急性脑梗死患者,稳定型脑梗死组20例,进展型脑梗死组20例,采用酶联免疫吸附法检测入院时血清中MMP-9含量,分析其与病情进展的关系。结果进展型脑梗死组MMP-9含量高于稳定型脑梗死组,MMP-9高值组进展率明显高于低值组。结论入院时血清MMP-9含量可作为评估急性脑梗死病情进展的一项指标。

Objective To evaluate the prediction significance of matrix metalloproteinase-9（MMP-9） in the progress of acute cerebral infarction.Methods Forty acute ischemic stroke patients were enrolled,including 20 patients in stable cerebral infarction group,and 20 patients in progressive cerebral infarction group.The serum specimens were gathered for MMP-9 determination with ELISA on admission to define their potential roles in the progressive cerebral infarction.Results Serum MMP-9 levels in the progressive cerebral infarction group were higher than those in the stable cerebral infarction group.The progressive ratio in the serum MMP-9〉140 ng/mL was significantly higher than that in the serum MMP-9 ≤140 ng/mL.Conclusion MMP-9 levels on admission would be an important evaluating index of the progress of acute cerebral infarction.