红花黄素对豚鼠心室乳头肌缺氧和复氧损伤的保护作用

Protection of Carthamfutinctorius on Transmembrane Potentials in Papillary Myocardium of Guinea Pig under Anoxia and Reoxygenation

观察了缺氧、复氧对豚鼠心肌细胞膜电位的影响及红花黄素的保护作用。结果表明，缺氧５～２５ｍｉｎ时ＲＰ、ＡＰＡ减小，Ｖｍａｘ减慢，ＡＰＤ１０、ＡＰＤ５０、ＡＰＤ９０缩短。复氧５～２０ｍｉｎ后，ＲＰ、ＡＰＡ和Ｖｍａｘ进一步减小，ＡＰＤ１０、ＡＰＤ５０、ＡＰＤ９０明显缩短。在灌流液中加入红花注射液保持其浓度在１％时，ＲＰ、ＡＰＡ显著增加，Ｖｍａｘ增快，ＡＰＤ１０、ＡＰＤ５０、ＡＰＤ９０明显延长。复氧２０ｍｉｎ后膜电位各项参数趋向恢复正常。此结果提示，红花黄素对缺氧。

In this study, it was studied that the effect of carthamfutinctorius on transmembrane potentials in papillary myocardium of guinea pig. The results showed that RP, APA and V max were dereased; APD 10 , APD 50 and APD 90 were shortened markedly when anoxia continued 5～25min. All the parameters above were further low after reoxygenating for 5～20min, 1% carthamfutinctorius of had apparently the effect of increasing RP, APA, V max and prolonging APD 10 , APD 50 and APD 90 , which recovered to normal after reoxygenating 20min. It is indicated that carthamfutinctorius possessed protective effect on anoxic and reoxygenated papillary myocardium.