胃肠道间质瘤中p-ERK和PTEN的表达及相互关系

Expressions of p-ERK and PTEN in Gastrointestinal Stromal Tumors and Their Interrelation

目的:研究胃肠道间质瘤(GIST)中p-ERK和PTEN蛋白的表达,并探讨二者之间的关系。方法:采用免疫组织化学方法检测124例GIST患者及癌旁正常组织中p-ERK和PTEN的表达水平,并进行比较分析。结果:GIST组织中p-ERK蛋白表达阳性率84.68%,明显高于正常组织(16.13%);PTEN蛋白表达的阳性率60.48%,明显低于正常癌旁组织(100%),差异有显著性(P<0.01);p-ERK和PTEN的表达与性别、年龄以及组织学类型无关,与NIH分级、淋巴结转移及浸润深度有关;p-ERK与PTEN表达呈负相关。结论:p-ERK的高表达、PTEN的低表达共同促进了GIST的发展。

Objective：To investigate the expression of p-ERK,and PTEN proteins in gastrointestinal stromal tumors （GIST） and their interrelation. Methods：p-ERK and PTEN expressions in GIST and normal tissues of 124 patients were detected by using immunohistochemistry method,and the results were analized. Results：The positive rate of p-ERK protein expression in GIST tissue （84.68%） was significantly higher than that in normal tissues （16.113%）,while the positive rate of PTEN protein expression in GIST tissue （60.48%） was lower than that in normal tissue （100%） with statistically significance （P0.01）; Expressions of p-ERK and PTEN appeared to relate to NIH grading,lymphonode metastasis,and infiltration depth,but not to gender,age or tissue types. Expression of p-ERK and PTEN showed a negative correlation to each other. Conclusions：High expression of p-ERK,together with low expression of PTEN,propels the development of GIST,which may throw light to development of new anti-tumor drug and clinical tumor therapy.