基于蒙特卡罗仿真的脑内部组织水分子自扩散模型研究

A Study of Brain Inner Tissue Water Molecule Self-diffusion Model Based on Monte Carlo Simulation

水分子自扩散特性的研究不仅对脑内部组织生理解剖结构信息的获取具有极其重要的意义,而且对于某些药物在脑内扩散传递过程的研究也有重要参考价值。从脑内部组织具有的生理结构特点出发,总结水分子自扩散模型,并利用蒙特卡罗仿真计算不同结构条件下的水分子自扩散系数。蒙特卡罗仿真计算结果与Latour扩散模型计算结果比较表明,随着扩散加权时间的延长,两个结果越来越接近,进一步验证了Latour模型是一个长扩散加权时间模型。

The study of water molecule self-diffusion process is of importance not only for getting anatomical information of brain inner tissue,but also for shedding light on the diffusion process of some medicine in brain tissue. In this paper,we summarized the self-diffusion model of water molecule in brain inner tissue,and calculated the self-diffusion coefficient based on Monte Carlo simulation under different conditions. The comparison between this result and that of Latour model showed that the two self-diffusion coefficients were getting closer when the diffusion time became longer,and that the Latour model was a long time-depended self-diffusion model.