微血管中铁磁性药物微粒靶向聚集特性的研究

A Study on the Targeting Collect Character of Ferromagnetic Drug Carrier Particles in Microvasculature

采用数值方法研究包裹有放射性纳米铁核素微粒的抗肿瘤药物在人体微血管中的输运和靶向聚集特征,分析药物在人体微血管中主要受到的外磁场吸引力和血流拖曳力的作用。研究结果表明,药物能够在病灶附近富集。另外,还分别研究了肿瘤的深度、药物中放射性纳米铁核素的含量、血流速度和血管的直径等对药物收集率的影响。

The transport and capture of therapeutic magnetic particles in the human microvasculature is studied numerically. Taking into account the dominant magnetic and fluidic forces on the particles,we have shown in our study that the particles can be directed to and concentrated at the desired zone which is within a few centimeters from the surface of the body. In addition,we have analyzed the influences of the malignant tissue depth,of the nanometers-iron nuclide content in a particle,and of the blood flow velocity and blood vessel diameter upon the captured efficiency.