Wave Intensity技术在慢性心力衰竭患者中的应用研究

Carotid Arterial Wave Intensity in Assessing the Hemodynamic Change in Patients with Chronic Heart Failure

Wave Intensity(WI)是新近提出的一种综合评价心血管系统功能的血流动力学参数。应用WI技术测量16例慢性心力衰竭患者和35例健康志愿者的颈动脉WI参数,包括W1、W2、NA、R-W1、W1-W2,探讨WI技术评估慢性心力衰竭(CHF)患者心血管总体功能的应用价值。结果发现,与正常对照组比较,慢性心力衰竭组除W1、W2峰值明显减小外(分别为5.44±3.24比10.05±6.33,P<0.01;0.83±0.42比1.50±0.95,P<0.01),时间指标R-W1明显延长(141.06±41.14比109.77±22.50,P<0.05),W1-W2明显缩短(214.63±39.93比260.51±20.58,P<0.01),R-W1/W1-W2比值明显增大(0.69±0.26比0.43±0.10,P<0.01)。WI技术能够提供丰富的心脏与血管相互作用的动态信息,可作为一种定量分析慢性心力衰竭的新方法。

Wave intensity （WI） is a newly proposed hemodynamic index that assesses the working condition of cardiovascular system. The purpose of this study is to investigate the clinical value of WI in assessing the function of cardiovascular system in patients with chronic heart failure （CHF）. We used a combined Doppler and echo-tracking system to calculate the carotid artery WI in 16 patients with CHF and 35 normal subjects,and examined the characteristics of WI. The main WI indices included W1,W2,NA,R-W1 and W1-W2. Compared with those in the control group,W1 and W2 were significantly decreased in CHF group （5.44±3.24 vs 10.05±6.33,P0.01;0.83±0.42 vs 1.50±0.95,P0.01,respectively）,the temporal indices R-W1 shortened （141.06±41.14 vs 109.77±22.50,P0.05） and W1-W2 prolonged （214.63±39.93 vs 260.51±20.58,P0.01）,and the （R-W1）/（W1-W2） ratio was significantly larger in CHF group （0.69±0.26 vs 0.43±0.10,P0.01）. WI provides a great deal of information about the dynamic behavior of the interaction between the heart and vascular system,so it is a new quantitative approach for analysis of CHF.