摘要
以壳聚糖为载体、月桂酸为原料,制备出一种疏水型低密度脂蛋白胆固醇(LDL-C)选择性吸附剂。考察了吸附时间和吸附剂用量对血浆LDL-C吸附效果的影响,得到合适的吸附条件。体外间歇吸附结果表明,LDL-C的平均吸附率达到84.7%,血浆总胆固醇(TC)平均吸附率达到47.7%,而对高密度脂蛋白胆固醇(HDL-C)与血浆总蛋白(TP)的平均吸附率分别仅为18.1%和5.9%,具有良好的选择性吸附低密度脂蛋白胆固醇的性能。
A hydrophobic low-density lipoprotein cholesterol （LDL-C） adsorbent was synthesized with lauric acid and chitosan. The condition for adsorption was obtained by investigating the influence of adsorbent amount and adsorption time. The results of adsorption in vitro showed that the average adsorption rates for total cholesterol （TC）,LDL-C,high-density lipoprotein cholesterol （HDL-C） and total protein （TP） were 47.7%,84.7%,18.1% and 5.9% respectively. The adsorbent possesses good selectivity in removing LDL-C.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2010年第3期671-674,共4页
Journal of Biomedical Engineering
关键词
壳聚糖
月桂酸
低密度脂蛋白胆固醇吸附剂
Chitosan
Lauric acid
Low-density lipoprotein cholesterol adsorbent
