摘要
重型乙型肝炎病情进展迅猛,病死率高,严重危害人类健康。其发病机制复杂,本文主要从病毒因素和宿主因素两方面进行综述,包括病毒基因型、病毒变异以及免疫反应与细胞因子等近年来重型乙型肝炎发病机制的研究进展,为更深入地了解其发病机制以及在今后的临床诊疗中寻找新的靶点提供参考。
Severe hepatitis B is an infectious disease which has high case fatality rate and is seriously harmful to human health. Its pathogenesis is complicated. In this article are reviewed the research reports on the virus and the host factors in the course of severe hepatitis B in recent years,including the advancement of researches on viral genotypes,viral mutations,immune responses and cytokines. These data are available for exploring the pathogenesis and for developing the clinical treatment of severe hepatitis B in future.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2010年第3期696-701,共6页
Journal of Biomedical Engineering
基金
国家重点基础研究计划资助项目(2007CB512902
2006CB504302)
关键词
重型肝炎
基因型
突变
细胞因子
Severe hepatitis
Genotypes
Mutation
Cytokines